Dr. Rubenstein's research focuses on basic and translational studies of novel means to improve outcomes in cystic fibrosis. He initially focused on correcting the dysfunction of mutant cystic fibrosis transmembrane conductance regulator (CFTR) proteins, which led him to study how molecular chaperones regulate the biogenesis and trafficking of CFTR and other proteins that are relevant to cystic fibrosis.
Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.
The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases.
Elaine H. Zackai, MD, Professor of Pediatrics in Genetics, will be presenting “Where Have All the Fellows Gone? Progress Over a Span of 48 Years” and Michael Marks, PhD, Professor of Pathology and Laboratory Medicine, will be presenting "The Dark Side of Subcellular Organelle Biogenesis Enlightened by the Hermansky-Pudlak Syndromes".