The research interests of Dr. Downes focus on antimicrobial clinical pharmacology and pharmacoepidemiology in children with a goal to identify novel approaches to optimize efficacy, minimize toxicity, and limit antimicrobial resistance from antibiotics.
As we approach the end of 2016, for good or ill, this time of year lends itself to reflection. To look back over these 12 months in research at Children's Hospital of Philadelphia, we've decided to pick 12 of the most popular stories we've brought you in the past year. While any year has its hardships and its triumphs, we're
Sometimes half is better than whole. That's the idea behind a new multicenter study that Children's Hospital of Philadelphia is participating in to compare a five-day (short) course of antibiotic therapy with a 10-day (standard) course of therapy to treat community-acquired pneumonia (CAP) in children. Pneumonia is a lung infection that is the leading infectious cause of death in children
One of the biggest looming threats to humanity's future is a monster of our own inadvertent creation. This isn't a summer superhero movie plot. It's the frightening reality of antibiotic-resistant strains of bacteria and other microbes, which arise over time as more bugs are exposed to more drugs, and evolve resistance to their effects.
The American Academy of Otolaryngology-Head and Neck Surgery published a guideline in 2011 recommending that “clinicians should not routinely administer or prescribe perioperative antibiotics to children undergoing tonsillectomies.”