Results for Anaplastic Lymphoma Kinase Genes

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Dr. Mossé's research goal is to improve cure rates for the childhood cancer neuroblastoma by discovering the genetic basis of the disease and translating rational therapeutic opportunities to the clinic. She studies the contribution of DNA sequence variations and activation mutations of anaplastic lymphoma kinase (ALK) genes on the development and progression of both inherited and acquired forms of neuroblastoma.

E-mail:

mosse [at] chop.edu

In the News: Impact Report, FDA Approval, PRESERVE Town Hall, ‘Immature Neurons,’ Lung Disease

Published on

Aug 5, 2022

in Cornerstone Blog

This week’s In the News highlights PolicyLab’s second annual Impact Report, an FDA approval based on CHOP research, and a link between daycare and chronic lung disease effects in premature infants.

In the News: Lymphoma Drug Approval, Fetal Therapy, NTRK Fusions, Infection Control at COVID Care Site, Epilepsy and Autism, Gift Supports Pediatric Brain Tumor Research

Published on

Jan 22, 2021

in Cornerstone Blog

This week’s In the News highlights a new drug approval for anaplastic large cell lymphoma based on research from CHOP.

In the News: Mitochondrial Gene Variance, Killing Cancer Cells, NICU Stress Effects, Visually Impaired Driver Safety

Published on

Mar 22, 2019

in Cornerstone Blog

In this week’s roundup, our researchers make impactful discoveries in genetics, cancer treatment, and more.

Antibody-drug conjugate shows efficacy against cell surface protein in neuroblastoma

Published on

Mar 13, 2019

in Press Releases

Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia (CHOP) have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells.

Intelligence Meets Inspiration: Celebrating Women in STEM at CHOP

Published on

Mar 8, 2019

in Cornerstone Blog

Seven women in science at CHOP share what drives them and the challenges that made them who they are today.

Patricia Brophy Chair Holds ‘Immeasurable’ Meaning for Yael Mossé, MD

Published on

Mar 6, 2019

in Cornerstone Blog

For its inaugural holder, the Patricia Brophy Endowed Chair has a special meaning rooted in a friendship that began nearly two decades ago.

Borrowing a Weapon From Leukemia’s Arsenal to Develop New Immunotherapy Approaches

Published on

Jan 30, 2019

in Cornerstone Blog

Basic and bioinformatics scientists at CHOP and Penn are working hard to unravel how leukemia cells resist CAR T-cell therapy.

In the News: Study Tops Most-Read List, the Migratory T Cell Response, Mossé Named Endowed Chair, ‘Healthier Together’ Launches, Supporting Survivors

Published on

Dec 28, 2018

in Cornerstone Blog

In this week’s roundup, CHOP launches a partnership to help the most vulnerable kids with asthma, and research supports a holistic approach to recovery from violence.

John Maris, MD, Receives National Cancer Institute Outstanding Investigator Award

Published on

Feb 26, 2018

in Cornerstone Blog

John Maris, MD, distinguished neuroblastoma researcher at CHOP, received the the National Cancer Institute's prestigious Outstanding Investigator Award.