Results for Adaptive Immune Mechanisms

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Dr. Seif's research centers on manipulating the human innate and immune systems to treat children with acute lymphoblastic leukemia (ALL). The long-term goal of her research is to identify innate and adaptive immune mechanisms that can be used to treat pediatric ALL more effectively, and with less toxicity, than existing therapies.

E-mail:

seifa [at] chop.edu

Craig H. Bassing, PhD

Dr. Bassing's research program focuses on the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

E-mail:

bassing [at] chop.edu

Researchers Propose ‘Roadmap’ to COVID-19 Vaccine Through Cancer Immunotherapy

Published on

Jun 11, 2020

in Cornerstone Blog

Neuroblastoma researchers shift their work toward strategizing a safe, effective vaccine against SARS-CoV-2.

2019 Distinguished Research Trainees Show Character and Creativity

Published on

Apr 11, 2019

in Cornerstone Blog

Meet the four recipients of our 2019 Distinguished Research Trainee Awards at CHOP Research Institute.

New Cancer Moonshot Grant Catalyzes Research for Immunotherapy in Childhood Cancer

Published on

Jan 9, 2019

in Cornerstone Blog

John M. Maris, MD, is leading a pediatric immuno-oncology Center for Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers with support from the NCI Moonshot Initiative.

Putting the Brakes on Allergic Response

Published on

Apr 21, 2016

in Cornerstone Blog

When you have a chronic allergic disorder, it’s easy to blame the trigger — an early pollen season or furry pet — but the real culprit is your own immune system. Designed to attack foreign substances such as bacteria and viruses, T cells are the immune system’s watchdog to recognize serious threats. But sometimes T cells can be too zealous and set in motion a signaling cascade that can cause allergic reactions to everyday things and even attack your body’s healthy cells by mistake.

Study Aims to Reveal Novel Drivers of Allergic Disease

Published on

Sep 8, 2014

in Cornerstone Blog

Investigators at The Children’s Hospital of Philadelphia are studying the underlying biological features that could be common from one allergic disease to another.

Seif Laboratory

The Seif Lab is focused on manipulating the human innate and immune systems to treat children with acute lymphoblastic leukemia (ALL).

Bassing Laboratory

The goals of research in the Bassing Lab are to elucidate the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

Mechanistic Molecular Immunology Lab

The Mechanistic Molecular Immunology Lab integrates cutting-edge structural biology and biochemistry tools with functional immunoassays to understand the molecular basis of immune responses to viral infections and tumors, with an emphasis on the development of novel protein-based therapeutics.