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Results for Acute Lymphoblastic Leukemia

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Stephen P. Hunger, MD
Stephen P. Hunger

Dr. Hunger's focuses his research on molecular and genomic approaches to identify and clinically evaluate targeted cancer treatments for children with relapsed or high-risk acute lymphoblastic leukemia (ALL) such as Philadelphia chromosome-like (Ph-Like) ALL. The long-term goal of Dr. Hunger’s research is to develop better therapies, improve cure rates, and minimize treatment toxicities for children with ALL.

E-mail:
hungers [at] email.chop.edu
Alix E. Seif, MD, MPH
Alix E. Seif

Dr. Seif's research centers on manipulating the human innate and immune systems to treat children with acute lymphoblastic leukemia (ALL). The long-term goal of her research is to identify innate and adaptive immune mechanisms that can be used to treat pediatric ALL more effectively, and with less toxicity, than existing therapies.

E-mail:
seifa [at] email.chop.edu
Stephan A. Grupp, MD, PhD
Stephan A. Grupp

Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.

E-mail:
grupp [at] email.chop.edu
Richard Aplenc, MD, PhD, MSCE
Richard Aplenc

Dr. Aplenc investigates ways to improve the outcomes of children with cancer, particularly acute myeloid leukemia, with clinical epidemiology studies and translational research.

E-mail:
aplenc [at] email.chop.edu
Carolyn A. Felix, MD
Carolyn A. Felix

Dr. Felix uses molecular, biochemical, cellular and in vivo methods to investigate the pathobiology of leukemias with KMT2A (MLL) translocations. Leukemias with these translocations affect infants and young children or occur as a complication of type II topoisomerase (TOP2) poison chemotherapies used for anti-cancer treatment. She aims to develop better treatment and prevention approaches for these leukemias, which have a poor prognosis.

E-mail:
felix [at] email.chop.edu
Susan R. Rheingold, MD
Susan R. Rheingold

Dr. Rheingold's research interests center on acute lymphocytic leukemia, and she serves on the Children's Oncology Group's Relapsed ALL, Infant ALL, and Complementary Therapies committees. In addition, she is investigates complementary and alternative therapies, supportive care for oncology patients undergoing chemotherapy, medical education, and rare childhood tumors.

E-mail:
rheingold [at] email.chop.edu
Wei Tong, PhD
Wei Tong

Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.

E-mail:
tongw [at] email.chop.edu
Shannon L. Maude, MD, PhD
Shannon L. Maude

Dr. Maude focuses on novel therapies for high-risk and relapsed pediatric acute lymphoblastic leukemia (ALL). She aims to identify new pediatric ALL treatments that are more effective, less toxic, and exhibit fewer side effects than existing cancer therapies.

E-mail:
maude [at] email.chop.edu
Alex Psihogios, PhD
Alex Psihogios, PhD

Dr. Psihogios' research focuses on improving treatment adherence in adolescents and young adults (AYA) with chronic medical conditions, particularly those with cancer. She uses real-time mobile health strategies to better understand the day-to-day factors that proximally impact treatment adherence.

E-mail:
psihogiosa [at] email.chop.edu
Sarah K. Tasian, MD
Sarah K. Tasian

Dr. Tasian's research centers on the bench-to-bedside investigation of precision medicine therapies for high-risk childhood leukemias.

E-mail:
tasians [at] email.chop.edu
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In this section

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  • Jill and Mark Fishman Center for Lymphatic Disorders (1)
  • Mitochondrial Medicine (1)
  • Office of Academic Training and Outreach Programs (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Thomas-Tikhonenko Laboratory (1)
  • West Philadelphia Asthma Care (1)

In this section

Filter By

  • Principal Investigator / Faculty (14)
  • Research Administration (1)

Organizations

  • Division of Oncology (23)
  • Center for Childhood Cancer Research (20)
  • Cancer Immunotherapy (CAR-T) (10)
  • Center for Autism Research (8)
  • Center for Injury Research and Prevention (7)
  • Children’s Oncology Group (7)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (6)
  • Department of Pediatrics (5)
  • Center for Pediatric Clinical Effectiveness (3)
  • Division of Hematology (3)
  • PolicyLab (3)
  • Center for Applied Genomics (2)
  • Center for Child Injury Prevention Studies (2)
  • Department of Anesthesiology and Critical Care Medicine (2)
  • Department of Radiology (2)
  • Division of Cancer Pathobiology (2)
  • Division of Infectious Diseases (2)
  • Lifespan Brain Institute (2)
  • Center for Computational and Genomic Medicine (1)
  • Center for Mitochondrial and Epigenomic Medicine (1)
  • Center for Pediatric Airway Disorders (1)
  • Center for Violence Prevention (1)
  • Department of Biomedical and Health Informatics (1)
  • Department of Pathology and Laboratory Medicine (1)
  • Division of Adolescent Medicine (1)
  • Division of Emergency Medicine (1)
  • Division of Neonatology (1)
  • Immune Dysregulation Program (1)
  • Jill and Mark Fishman Center for Lymphatic Disorders (1)
  • Mitochondrial Medicine (1)
  • Office of Academic Training and Outreach Programs (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Thomas-Tikhonenko Laboratory (1)
  • West Philadelphia Asthma Care (1)
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