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Results for Acute Lymphoblastic Leukemia

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Stephen P. Hunger, MD
Stephen P. Hunger

Dr. Hunger's focuses his research on molecular and genomic approaches to identify and clinically evaluate targeted cancer treatments for children with relapsed or high-risk acute lymphoblastic leukemia (ALL) such as Philadelphia chromosome-like (Ph-Like) ALL. The long-term goal of Dr. Hunger’s research is to develop better therapies, improve cure rates, and minimize treatment toxicities for children with ALL.

E-mail:
hungers [at] chop.edu
Alix E. Seif, MD, MPH
Alix E. Seif

Dr. Seif's research centers on manipulating the human innate and immune systems to treat children with acute lymphoblastic leukemia (ALL). The long-term goal of her research is to identify innate and adaptive immune mechanisms that can be used to treat pediatric ALL more effectively, and with less toxicity, than existing therapies.

E-mail:
seifa [at] chop.edu
Richard Aplenc, MD, PhD, MSCE
Richard Aplenc

Dr. Aplenc investigates ways to improve the outcomes of children with cancer, particularly acute myeloid leukemia, with clinical epidemiology studies and translational research.

E-mail:
aplenc [at] chop.edu
Stephan A. Grupp, MD, PhD
Stephan A. Grupp

Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.

E-mail:
grupp [at] chop.edu
Carolyn A. Felix, MD
Carolyn A. Felix

Dr. Felix uses molecular, biochemical, cellular and in vivo methods to investigate the pathobiology of leukemias with KMT2A (MLL) translocations. Leukemias with these translocations affect infants and young children or occur as a complication of type II topoisomerase (TOP2) poison chemotherapies used for anti-cancer treatment. She aims to develop better treatment and prevention approaches for these leukemias, which have a poor prognosis.

E-mail:
felix [at] chop.edu
Susan R. Rheingold, MD
Susan R. Rheingold

Dr. Rheingold's research interests center on acute lymphocytic leukemia, and she serves on the Children's Oncology Group's Relapsed ALL, Infant ALL, and Complementary Therapies committees. In addition, she is investigates complementary and alternative therapies, supportive care for oncology patients undergoing chemotherapy, medical education, and rare childhood tumors.

E-mail:
rheingold [at] chop.edu
Wei Tong, PhD
Wei Tong

Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.

E-mail:
tongw [at] chop.edu
Shannon L. Maude, MD, PhD
Shannon L. Maude

Dr. Maude focuses on novel therapies for high-risk and relapsed pediatric acute lymphoblastic leukemia (ALL). She aims to identify new pediatric ALL treatments that are more effective, less toxic, and exhibit fewer side effects than existing cancer therapies.

E-mail:
maude [at] chop.edu
Sarah K. Tasian, MD
Sarah K. Tasian

Dr. Tasian's research centers on the bench-to-bedside investigation of precision medicine therapies for high-risk childhood leukemias.

E-mail:
tasians [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
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In this section

Filter By

  • Principal Investigator / Faculty (14)
  • Research Administration (1)

Organizations

  • Division of Oncology (40)
  • Center for Childhood Cancer Research (35)
  • Cancer Immunotherapy (CAR-T) (18)
  • Department of Pediatrics (10)
  • Center for Autism Research (8)
  • Division of Infectious Diseases (8)
  • Center for Injury Research and Prevention (7)
  • Children’s Oncology Group (7)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (7)
  • Center for Applied Genomics (5)
  • Clinical Futures (5)
  • Division of Cancer Pathobiology (5)
  • Division of Hematology (5)
  • PolicyLab (5)
  • Cell and Gene Therapy Collaborative (4)
  • Department of Pathology and Laboratory Medicine (4)
  • Center for Computational and Genomic Medicine (3)
  • Division of Allergy and Immunology (3)
  • Center for Child Injury Prevention Studies (2)
  • Clinical In Vivo Gene Therapy (2)
  • Department of Anesthesiology and Critical Care Medicine (2)
  • Department of Radiology (2)
  • Division of Neurology (2)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (2)
  • Immune Dysregulation Program (2)
  • Lifespan Brain Institute (2)
  • Mitochondrial Medicine (2)
  • Thomas-Tikhonenko Laboratory (2)
  • Anderson Laboratory (1)
  • Brain-Gene-Development Lab (1)
  • Center for Mitochondrial and Epigenomic Medicine (1)
  • Center for Pediatric Airway Disorders (1)
  • Center for Spatial and Functional Genomics (1)
  • Center for Violence Prevention (1)
  • CHOP Microbiome Center (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • Department of Biomedical and Health Informatics (1)
  • Division of Adolescent Medicine (1)
  • Division of Cardiology (1)
  • Division of Emergency Medicine (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Gastroenterology, Hepatology, and Nutrition (1)
  • Division of Human Genetics (1)
  • Division of Neonatology (1)
  • Division of Ophthalmology (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Food Allergy Center (1)
  • Jill and Mark Fishman Center for Lymphatic Disorders (1)
  • Jolley Laboratory (1)
  • Mir Laboratory (1)
  • Novel Therapeutics for Bleeding Disorders (1)
  • Office of Academic Training and Outreach Programs (1)
  • Office of the Ruth M. Colket Chair Pediatric Nursing Science (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Tasian Laboratory (1)
  • West Philadelphia Asthma Care (1)
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