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Yimei Li, PhD
Faculty Biostatistician
Dr. Li’s methodology research interests include clinical trial design, survival analysis, longitudinal data analysis, and statistical methods for health services research. The current focus of her research is on statistical designs and analyses for early phase cancer clinical trials, such as Bayesian adaptive designs for dose-finding trials and platform trials. Her collaborative research focuses on pediatric oncology, ranging from translational research to clinical trials and epidemiology studies.
Bio
Dr. Yimei Li is a faculty member in the Department of Pediatrics at Children’s Hospital of Philadelphia, an assistant professor of Biostatistics in the Department of Biostatistics, Epidemiology and Informatics, and a senior scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania’s Perelman School of Medicine.
Dr. Li’s methodology research interests include clinical trial design, survival analysis, longitudinal data analysis, and statistical methods for health services research. Her earlier research focused on survival analysis, specifically statistical methodology for multivariate time-to-event data with alternating states and a possibility of cure. Recently, she has focused her research on statistical designs and analyses for early phase cancer clinical trials, such as Bayesian adaptive designs for dose-finding trials and platform trials.
Dr. Li’s collaborative research focuses on pediatric oncology, including basic and translational research to understand tumor biology, clinical trials to evaluate experimental cancer therapies, epidemiological studies using real world data (RWD) such as administrative database and electronic health records (EHR), and behavioral and psycho-social studies that aim to help oncology patients/families cope and adjust to their medical experience. She has extensive experience in design, conduct and analysis of various cancer studies, and have published over 130 articles in the literatures of statistical methodology, cancer research, and other areas of medicine. She is also on the editorial board of the Journal of National Cancer Institute.
Education and Training
BS, Peking University (Applied Mathematics), 2006
MS, University of Pennsylvania (Biostatistics), 2008
PhD, University of Pennsylvania (Biostatistics), 2010
Titles and Academic Titles
Assistant Professor of Biostatistics
Assistant Professor of Pediatrics
Professional Memberships
American Statistical Association, 2007-
International Biometric Society, 2007-
International Chinese Statistical Association, 2011-
Caucus for Women in Statistics, 2019-
Society for Epidemiologic Research, 2020-
Publication Highlights
Pubmed:
Li Y, Yuan Y. PA-CRM: A continuous reassessment method for pediatric phase I oncology trials with concurrent adult trials. Biometrics. 2020 Jan; PMID: 31950483
Li Y, Wang M, Cheung K. Treatment and dose prioritization in early phase platform trials of targeted cancer therapies. J Royal Statistical Society: Series C (Applied Statistics). 2019 Jan; doi: 10.1111/rssc.12324
Li Y, Zhang Qok g. A Weibull multi-state model for the dependence of progression-free survival and overall survival. Stat Med. 2015 Jul; 34(17): 2497-2513. doi: 10.1002/sim.6501 Epub 2015 Apr 10. PMID: 25865438
Li Y, Mick R, Heitjan DF. Suspension of accrual in phase II cancer clinical trials. Clinical Trials. 2015 Apr; 12(2): 128-138. doi: 10.1177/1740774514562029 Epub 2015 Jan 7. PMID: 25568092
Li Y, Wileyto EP, Heitjan DF. Prediction of individual long-term outcomes in smoking cessation trials using frailty models. Biometrics. 2011 Dec; 67(4): 1321-1329. doi: 10.1111/j.1541-0420.2011.01578.x. Epub 2011 Mar 14. PMID: 21401566