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kumars [at]
Location - People View
3rd Floor, Room 310 C

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Shekhar Kumar, PhD
Shekhar Kumar, PhD
Research Assistant Professor

Dr. Kumar's research focuses on structure and function of proteins in blood coagulation. Using a coupled structural and biochemical approach, his lab studies molecular mechanisms underlying coagulation with a goal to understand how the tertiary structure determines the function of coagulation proteins



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Education and Training

BS, Patna University (Biotechnology), Patna, India, 2000

MS, All India Institute Of Medical Sciences (Biotechnology), New Delhi, India, 2003

PhD, Jawaharlal Nehru University (Biochemistry), New Delhi, India, 2010

Fellowship, Children’s Hospital of Philadelphia

Titles and Academic Titles

Research Assistant Professor

Professional Memberships

American Society of Hematology, 2011-

North American Society on Thrombosis and Hemostasis, 2013-

International Society on Thrombosis and Haemostasis, 2013-

Professional Awards

Mary Rodes Gibson Memorial Award in Hemostasis and Thrombosis, American Society of Hematology, 2015

Judith Graham Pool Postdoctoral Research Fellowships Award, 2016

Publication Highlights

Soule EE, Yu H, Olson L, Naqvi I, Kumar S, Krishnaswamy S, Sullenger BA. Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples. Cell Chem Biol. 2022 Feb; 29(2): 215-225.e5. PMID: 35114109
Sharma V, Kumar S, Sahni G. Kringles of substrate plasminogen provide a 'catalytic switch' in plasminogen to plasmin turnover by Streptokinase. Biochem J. 2020 Mar; 477(5): 953-970. PMID: 32069359
Gunaratne R, Kumar S, Frederiksen JW, Stayrook S, Lohrmann JL, Perry K, Bompiani KM, Chabata CV, Thalji NK, Ho MD, Arepally G, Camire RM, Krishnaswamy S, Sullenger BA. Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nat Biotechnol. 2018 Aug; 36(7):606-613. PMID: 29863725
Sawhney P, Kumar S, Maheshwari N, Guleria SS, Dhar N, Kashyap R, Sahni G. Site-Specific Thiol-mediated PEGylation of Streptokinase Leads to Improved Properties with Clinical Potential. Curr Pharm Des. 2016 Jan; 22(38): 5868-5878. PMID: 26845325