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Shekhar Kumar, PhD
Research Assistant Professor
Dr. Kumar's research focuses on structure and function of proteins in blood coagulation. Using a coupled structural and biochemical approach, his lab studies molecular mechanisms underlying coagulation with a goal to understand how the tertiary structure determines the function of coagulation proteins
Education and Training
BS, Patna University (Biotechnology), Patna, India, 2000
MS, All India Institute Of Medical Sciences (Biotechnology), New Delhi, India, 2003
PhD, Jawaharlal Nehru University (Biochemistry), New Delhi, India, 2010
Fellowship, Children’s Hospital of Philadelphia
Titles and Academic Titles
Research Assistant Professor
Professional Memberships
American Society of Hematology, 2011-
North American Society on Thrombosis and Hemostasis, 2013-
International Society on Thrombosis and Haemostasis, 2013-
Professional Awards
Mary Rodes Gibson Memorial Award in Hemostasis and Thrombosis, American Society of Hematology, 2015
Judith Graham Pool Postdoctoral Research Fellowships Award, 2016
Publication Highlights
Soule EE, Yu H, Olson L, Naqvi I, Kumar S, Krishnaswamy S, Sullenger BA. Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples. Cell Chem Biol. 2022 Feb; 29(2): 215-225.e5. PMID: 35114109
Sharma V, Kumar S, Sahni G. Kringles of substrate plasminogen provide a 'catalytic switch' in plasminogen to plasmin turnover by Streptokinase. Biochem J. 2020 Mar; 477(5): 953-970. PMID: 32069359
Gunaratne R, Kumar S, Frederiksen JW, Stayrook S, Lohrmann JL, Perry K, Bompiani KM, Chabata CV, Thalji NK, Ho MD, Arepally G, Camire RM, Krishnaswamy S, Sullenger BA. Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nat Biotechnol. 2018 Aug; 36(7):606-613. PMID: 29863725
Sawhney P, Kumar S, Maheshwari N, Guleria SS, Dhar N, Kashyap R, Sahni G. Site-Specific Thiol-mediated PEGylation of Streptokinase Leads to Improved Properties with Clinical Potential. Curr Pharm Des. 2016 Jan; 22(38): 5868-5878. PMID: 26845325