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Dr. Camire's research focuses on understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. He is also interested in developing novel therapeutic approaches (protein, gene-based, small molecule) to mitigate these events, which are major causes of morbidity and mortality worldwide.
Dr. Camire is interested in understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. His group is developing therapeutic approaches to mitigate these events, which are major causes of morbidity and mortality worldwide.
His current areas of investigation include understanding how clotting factor cofactors work, such as factor V and VIII, and defining their mechanism of activation. Dr. Camire's lab uncovered surprising observations that have fundamentally shifted current thinking about FV activation and its regulation by tissue factor pathway inhibitor.
Dr. Camire investigates structural correlates of protease function-basic and translational research to understand how processing of inactive serine protease zymogens, such as FX and FIX, to their active forms contribute to the expression of binding sites critical to their function. Knowledge from these biochemical studies has been applied to translational studies to develop novel protein therapeutics to treat bleeding in hemophilia, trauma, or other conditions.
Other current areas of investigation include imaging coagulation reactions. Dr. Camire uses fluorescence approaches developed for physical studies of coagulation enzyme function to develop enabling technologies that permit quantitative measurements of enzyme complex assembly and function in vivo. He also employs protein, gene therapy, and other strategies to alleviate hemophilia A or B. Using different bioengineering strategies, he aims to modify FVIII or FIX with unique properties that could be useful in a gene-based approach.
Dr. Camire has been funded from the NIH since 2003 and has published over 70 primary and review articles related to blood coagulation, and work from his laboratory has led to over 15 patents. Dr. Camire is a recent International Society on Thrombosis and Haemostasis Biennial Awards for Contributions to Hemostasis awardee, and he also sits on the Editorial Board of Blood.
Education and Training
BA, Saint Anslem College (Biochemistry), 1994
PhD, University of Vermont (Biochemistry), 1998
Fellowship, Children's Hospital of Philadelphia (Biochemistry), 2001
Titles and Academic Titles
Professor of Pediatrics
Children’s Hospital of Philadelphia Endowed Chair in Pediatric Hematology
American Association for the Advancement of Science, 1998-
The American Society of Hematology, 2001-
American Heart Association, 2006-
International Society of Thrombosis and Hemostasis, 2006-
North American Society of Thrombosis and Hemostasis, 2013-
The American Society of Hematology, Scientific Committee on Hemostasis, 2014-2017
Young Investigator Award, Annual Meeting of the American Society of Hematology, 2000, 2001
Young Investigator Award, International Society on Thrombosis and Haemostasis, 2001, 2005
American Heart Association (Penn/Del) Research Award, 2003
Early Career Investigator Award, The Bayer Hemophilia Awards Program, Bayer Corp., 2005
Copernicus Visiting Scientist, IUSS-Ferrara 1391, University of Ferrara, Ferrara, Italy, 2009
Alumni Academic Achievement Award, Saint Anselm College, 2009
Martin Villar Haemostasis Award (1st Prize), 2012