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Richard Aplenc, MD, PhD, MSCE
Richard Aplenc
Assistant Vice President and Chief Clinical Research Officer

Dr. Aplenc investigates ways to improve the outcomes of children with cancer, particularly acute myeloid leukemia, with clinical epidemiology studies and translational research.

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Bio

Investigators at Children's Hospital of Philadelphia lead over 600 clinical trials aimed at improving pediatric care across all specialties. As chief clinical research Officer of CHOP Research Institute, Dr. Aplenc sets the course for the development and oversight of clinical research and clinical research operations across CHOP Research.

Dr. Aplenc’s research centers on pediatric acute myeloid leukemia (AML), with ongoing clinical epidemiology and translational research projects. His clinical epidemiology research focuses on improving adverse event reporting on clinical trials in the Children's Oncology Group (COG) by merging external data sets to COG clinical trial data. He also leverages data set merging for clinical epidemiology investigations in pediatric AML with a particular focus on cardio-oncology and disparities in treatment outcome.

Dr. Aplenc also leads a Patient-Centered Outcomes Research Institute effort to study medical and patient reported outcomes with various discharge practices after AML chemotherapy administration.

From a translational standpoint, he leads efforts to identify risk alleles for pediatric AML susceptibility and treatment response with genomewide genotyping and next generation sequencing. Finally, he led the recently completed phase III trial for children with AML in the COG and serves as the vice-chair of the COG Strategy AML Committee.

Education and Training

MD, University of Virginia (Medicine), 1994

MS, University of Pennsylvania (Epidemiology and Biostatistics), 2002

PhD, University of Pennsylvania (Epidemiology and Biostatistics), 2011

Titles and Academic Titles

Assistant Vice President and Chief Clinical Research Officer

Attending Physician

Professor of Pediatrics and Epidemiology

Professional Awards

Senior Teaching Award, UCSD Department of Pediatrics, 1997

Fellow Teaching Award, Children’s Hospital of Philadelphia, 1998

AACR-Bristol-Myers-Squibb Oncology Fellowship in Clinical Oncology Research, American Association for Cancer Research, 1999-2000

Clinical Scientist Training Award, Doris Duke Charitable Foundation, 2000-2005

Pfizer Scholar in Training Award, American Association for Cancer Research, 2003

Publication Highlights

Getz KD, Sung L, Ky B, Gerbing RB, Leger KJ, Leahy AB, Sack L, Woods WG, Alonzo T, Gamis A, Aplenc R. Occurrence of Treatment-Related Cardiotoxicity and Its Impact on Outcomes Among Children Treated in the AAML0531 Clinical Trial: A Report From the Children's Oncology Group. J Clin Oncol. 2019 Jan; 37(1):12-21. PMID: 30379624
Miller TP, Li Y, Kavcic M, Getz KD, Huang YV, Sung L, Alonzo TA, Gerbing R, Daves MH, Horton TM, Pulsipher MA, Pollard J, Bagatell R, Seif AE, Fisher BT, Luger S, Gamis AS, Adamson PC, Aplenc R. Center-level variation in accuracy of adverse event reporting in a clinical trial for pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Haematologica. 2017 Sep; 102(9):e340-e343. PMID: 28642300
Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R. Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report. Blood. 2017 Jun; 129(23):3051-3058. PMID: 28411282
Miller TP, Li Y, Getz KD, Dudley J, Burrows E, Pennington J, Ibrahimova A, Fisher BT, Bagatell R, Seif AE, Grundmeier R, Aplenc R. Using electronic medical record data to report laboratory adverse events. Br J Haematol. 2017 Apr; 177(2):283-286. PMID: 28146330
Miller TP, Li Y, Kavcic M, Troxel AB, Huang YS, Sung L, Alonzo TA, Gerbing R, Hall M, Daves MH, Horton TM, Pulsipher MA, Pollard JA, Bagatell R, Seif AE, Fisher BT, Luger S, Gamis AS, Adamson PC, Aplenc R. Accuracy of Adverse Event Ascertainment in Clinical Trials for Pediatric Acute Myeloid Leukemia. Clin Oncol. 2016 May; 34(13):1537-43. PMID: 26884558

Links of Interest