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Ophir Shalem, PhD
Ophir Shalem

Dr. Shalem’s research focuses on translational target discovery for a range of neurodegenerative diseases. He combines technology development of large-scale CRISPR-based perturbation screens with application of such technology together with additional genomic approaches.



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Dr. Shalem develops novel screening paradigms to study neurodegenerative diseases and PQC pathways. This includes developing fluorescence sensors for protein aggregation, processing, and stability followed by genome-wide CRISPR screening in human cell lines and neuronal and neuron-like cells derived from ESC and iPS cells.

In addition, Dr. Shalem and his lab are developing analytical frameworks to analyze the data that is being generated through those screens and to integrate it within other large-scale biological data sets.

Education and Training

BSc, Ben Gurion University (Computer Science, Biology), 2004

MSc, The Weizmann Institute of Science (Biology, Systems Biology), 2007

PhD, The Weizmann Institute of Science (Biology, Systems Biology), 2012

Fellowship, The Broad Institute of MIT and Harvard, McGovern Institute for Brain Research at MIT (Functional Genomics), 2016

Titles and Academic Titles


Assistant Professor of Genetics

Publication Highlights

Links of Interest