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Neil D. Romberg, MD
Neil D. Romberg
Investigator

Dr. Romberg investigates the regulatory mechanisms enabling our immune systems to fight infections without injuring ourselves. He is particularly interested in the immune system of patients with primary immunodeficiency who are susceptible to both life-threatening infections and autoimmune diseases. Greater insights into these rare diseases may enable rationale development of targeted therapies for more common diseases with an immunologic basis.

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Bio

Dr. Romberg investigates the regulatory mechanisms that enable our immune systems to vigorously attack infectious pathogens but not our own bodies. Particular topics of interest in Dr. Romberg's lab include the role of T regulatory cells in B cell tolerance, T follicular helper cell dysfunction in common variable immune deficiency-related autoimmune disease, and the role of novel genes and pathways in immunity.

Of particular interest to Dr. Romberg is the immune system of patients with primary immunological diseases (PID) who are susceptible to both life-threatening infections and to the development of autoimmune diseases. Greater insights into the pathology of these rare diseases will enable the rationale development of targeted therapies for PIDs and for more common diseases that have an immunologic basis.

In addition to basic scientific work, Dr. Romberg has discovered or has contributed to the discovery of several inherited diseases of the immune system and identified personalized therapies for affected patients. Such disorders include:

  • PU.1-mutated agammaglobulinemia (PU.MA)
  • CD40LG duplication associated autoimmune disease (40DAD)
  • Autoinflammation with infantile enterocolitis (AIFEC)

 

Education and Training

BS, University of Michigan (Botany), 1999

MD, Pennsylvania State College of Medicine, 2004

Fellowship, Yale University School of Medicine (Allergy and Clinical Immunology), 2011

Pediatric Residency and Chief Residency, New York University School of Medicine, 2008

Titles and Academic Titles

Investigator

Jeffrey Modell Endowed Chair in Pediatric Immunology Research

Attending Physician

Assistant Professor of Pediatrics

Professional Memberships

American Academy of Allergy, Asthma and Immunology, 2008-

Clinical Immunology Society, 2009-

University of Pennsylvania Institute for Immunology, 2015-

Professional Awards

Clinical Immunology Society/Talecris Primary Immune Deficiency Fellowship Award, 2011

Scholar of the NIH Child Health Research Center, 2012-2014

Timber Spears Endowment for Immunodeficiency Research Award Recipient, 2014-2015

Yale Center for Clinical Investigation Scholar Award, 2014-2015

Lady Barbara Colyton Prize for Autoimmune Research, 2021

Publication Highlights

Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson TS, Seif AE, Wertheim G, Grant SFA, Vo LT, Puck JM, Sullivan KE, Routes JM, Zakharova V, Shcherbina A, Mukhina A, Rudy NL, Hurst ACE, Atkinson TP, Boggon TJ, Hakonarson H, Abate AR, Hajjar J, Nicholas SK, Lupski JR, Verbsky J, Chinn IK, Gonzalez MV, Wells AD, Marson A, Poon GMK, Romberg N. Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients. J Exp Med. 2021 Jul; 218(7):e20201750. Epub 2021 May 5. PMID: 33951726; PMCID: PMC8105723
Le Coz C, Bengsch B, Khanna C, Trofa M, Ohtani T, Nolan BE, Henrickson SE, Lambert MP, Kim TO, Despotovic JM, Feldman S, Fadugba OO, Takach P, Ruffner M, Jyonouchi S, Heimall J, Sullivan KE, Wherry EJ, Romberg N. Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage. J Allergy Clin Immunol. 2019 Dec; 144(6):1660-1673. Epub 2019 Aug 22. PMID: 31445098; PMCID: PMC6900457
Le Coz C, Trofa M, Syrett CM, Martin A, Jyonouchi H, Jyonouchi S, Anguera MC, Romberg N. CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation. J Allergy Clin Immunol. 2018 Jun; 141(6):2308-2311.e7. Epub 2018 Mar 2. PMID: 29499223; PMCID: PMC5994181
Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat. Genet. 2014 Oct; 46(10):1135-1139. Epub 2014 Sep 14. PMID: 25217960; PMCID: PMC4177367