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obyrnem [at]
Location - People View
11th Floor

2716 South Street
Philadelphia, PA 19146
United States

Research Topics
Michael L. O'Byrne, MD, MSCE
Michael L. O’Byrne
Interventional Cardiologist

Dr. O'Byrne is a pediatric cardiologist with research interests in cardiac disease outcomes, perioperative outcomes, and children with pulmonary hypertension. He combines the use of large observational datasets to study outcomes, practice variation, cost, and the determinants of health-related quality of life in this population.



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Dr. O’Byrne's research focuses on improving outcomes in patients with congenital and acquired heart disease. To accomplish this, his research portfolio includes studies that leverage large observational datasets (clinical registries, administrative datasets, and claims databases) to assess quality of care and practice variation between hospitals, comparative effectiveness research, and economic outcomes.

Separately, he also leads a team evaluating patient-centered outcomes of patients and families with cardiac disease evaluating the biological and psychological determinants of health-related quality of life in this population. He is supported by a patient-centered career development award from the National Heart Lung and Blood Institute as well as project support from foundations.

Education and Training

AB, Harvard University (Neurobiology), 2001

MD, Columbia University, 2007

Fellowship, Children's Hospital of Philadelphia (Pediatric Cardiology), 2013

Fellowship, Children's Hospital of Philadelphia (CV Research), 2014

MSCE, University of Pennsylvania (Clinical Effectiveness), 2014

Fellowship, Children's Hospital of Philadelphia (Interventional Cardiology), 2015

Titles and Academic Titles

Interventional Cardiologist

Core Faculty, Clinical Futures

Assistant Professor of Pediatrics

Professional Memberships

American Heart Association, 2002-

American College of Cardiology, 2010-

Society for Cardiac Angiography and Intervention, 2013-

Society of Pediatric Research, 2018-

American Thoracic Society, 2018-

International Society for Heart and Lung Transplantation, 2018-

Professional Awards

Senior Resident Clinician Award, Children's Hospital of Philadelphia, 2010

Christopher J White, MD Early Career Reviewer Award, 2017

CVDY Young Investigator Award Finalist, American Heart Association, 2018

Publication Highlights

Links of Interest