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Dr. George's basic and clinical research studies include defining the molecular basis of coagulation and developing gene-based therapies for hemophilia.
Dr. George's laboratory studies the molecular basis of coagulation with a focus on mechanisms that regulate factor VIII/VIIIa cofactor function to improve understanding of associated disease states of deficiency (hemophilia A) or excess function (thrombosis). Ongoing studies in her group aim to exploit their biochemical insights of FVIII function to develop novel gene-based therapies for hemophilia A. Dr. George has led early-phase, adeno-associated virus (AAV)-mediated gene transfer trials for hemophilia A and B. Her Clinical In Vivo Gene Therapy research group conducts and supports translational and clinical research in in vivo gene therapy and also aims to implement licensed AAV vectors safely and efficiently across the institution.
Dr. George is a member of the Board of Directors of the American Society of Gene and Cell Therapy and participates in multiple and international professional societies for hemostasis and gene therapy research.
Education and Training
BS, Cornell University
MD, University at Buffalo School of Medicine
Pediatric Resident, Weill Cornell Medical College
Pediatric Chief Resident, Weill Cornell Medical College
Pediatric Hematology/Oncology fellowship, Children's Hospital of Philadelphia
MS, University of Pennsylvania (Translational Research)
Titles and Academic Titles
Tenure Assistant Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania
Director, Clinical In Vivo Gene Therapy Center, Children's Hospital of Philadelphia
Attending Hematologist, Children's Hospital of Philadelphia
International Society of Thrombosis and Haemostasis World Federation of Hemophilia, 2013-
World Federation of Hemophilia, 2017-
American Society of Hematology, 2010-
American Society of Gene and Cell Therapy, 2015-
Hemostasis and Thrombosis Research Society, 2015-
2017 Eberhard Mammen Young Investigator Award for Excellence in Thrombosis and Hemostasis, San Diego, CA
2018 Professor Heimburger Award in Hemostasis, Marburg, Germany
2019 National Top 10 Clinical/Translational Research Award, Clinical Research Forum, Washington, D.C.
2019 Scholar Award of the National Blood Foundation, Washington, D.C.
2020 Martin Villar Basic Science Award
2022 Young Physician-Scientist Award, American Society of Clinical Investigation
2022 Outstanding New Investigator, American Society of Gene and Cell Therapy