Abramson Pediatric Research Center, Room 702 The Children's Hospital of Philadelphia 34th & Civic Center Blvd.

chemical approaches for drug and biomaterials modification; prodrug and codrug synthesis

Research Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (2003– present)
Research Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1997 – 2003)
Ph.D., Chemistry, Novosibirsk State University, USSR, work done at the Institute of Chemical Kinetics and Combustion (1978)
M.S., Chemistry, Novosibirsk State University, Novosibirsk, USSR (1968)
Selected Publications
Alferiev, I.S., Fishbein, I.. Activated polyurethane modified with latent thiol groups. Biomaterials. Vol 23. 2002:4753-4758.
Alferiev, I.S.. Novel elastomeric polyurethanes with pendant epoxy groups as highly reactive auxiliary groups for further derivatizations. Journal of Polmer Science: Part A: Polymer Chemistry. Vol 40. 2002:4378-4385.
Alferiev, I.S., Stachelek, S.J., Song, C., Connolly, M., Bianco, R.W., Levy, R.J.. Gene delivery from polyurethane heart valve cusps and vascular implants. 28th Annual meeting of the Society for Biomaterials. Tampa Florida. (518) . 2002.
Alferiev, I.S., Vyavahare, N.R., Song, C.X., Levy, R.J.. Elastomeric polyurethanes modified with geminal bisphosphonate groups. Journal of Polymer Science: Part A: Polymer Chemistry. Vol 39. 2001:105-116.
Alferiev, I.S., Hinson, J.T., Ogle, M., Breuer, E., Levy, R.J.. High reactivity of alkyl sulfides towards epoxides under conditions of collagen fixation - a convenient approach to 2-amino-4-butyrolactones. Biomaterials. Vol 22. 2001:2501-2506.
Alferiev, I.S., Vyavahare, N.R., Song, C.X., Connoly, J., Hinson J.T. Lu, Zh.B., Tallapragada, S., Bianco, R., Levy, R.J.. Bisphosphonate derivatized polyurethanes resist calcificaton. Biomaterials. Vol 22. 2001:2683-2693.
Ezra, A., Hoffman, A., Breuer, E., Alferiev, I.S., Mönkönen, El Hanany-Rozen, N., Weiss, G., Stepinsky, D., Gati, I., Cohen, H., Törmälehto, Amidon, G.L., Golomb, G.. A peptide prodrug approach for improving bisphosphonate oral absorption. Journal of Medicinal Chemistry. Vol 43. 2000:3641-3652.
Vyavahare, N.R., Alferiev, I.S., Levy, R.J.. Bisphosphonate modified polyurethanes resist calcification.. Society for Biomaterials Proceedings. Hawaii. Vol 1111. 2000 May.
Martin, V.V., Alferiev, I.S., Weis, A.L.. Amplified fluorescent molecular probes based on 1,3,5,7-tetrasubstituted adamantane. Tetrahedron Letters. Vol 40(2). 1999:223-226.
Weis, A.L., Bakos,T., Alferiev, I.S., Zhang, X., Shao, B., Kinney, W.A.. Synthesis of an azido spermidine equivalent. Tetrahedron Letters. Vol 40(26). 1999:4863-4864.