In This Section

Evan Weber, PhD
Evan W. Weber
Assistant Professor of Pediatrics

Dr. Weber is developing approaches to enhance CAR-T cell therapies for pediatric cancer by reprogramming T cells with improved durability and exhaustion resistance. His work will uncover molecular mechanisms that promote CAR-T cell exhaustion and identify new targets for therapeutic intervention.

AddtoAny
Share:

WATCH THIS PAGE

Subscribe to be notified of changes or updates to this page.

5 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Bio

Dr. Weber's research is focused on developing methods to enhance human CAR-T cell therapies for pediatric cancer by endowing T cells with improved durability and exhaustion resistance. His laboratory specializes in modeling and interrogating CAR-T cell exhaustion, a biological process that limits CAR-T cell efficacy in patients. Utilizing an array of pharmacologic, gene-editing, and bioengineering approaches, Dr. Weber and his team are working to identify and modulate transcriptional and epigenetic pathways that redirect human T cells away from exhaustion and towards more therapeutic cell states.

Ongoing work integrates multi-omics analyses on experimental and patient CAR-T cells to identify and link specific epigenetic features to cell phenotype, function, and patient outcomes, thereby informing his lab's T cell engineering efforts. Collectively, Dr. Weber's research will uncover molecular programs that drive human CAR-T cell dysfunction, identify targets for therapeutic intervention, and inform universal strategies that improve CAR-T cell efficacy in cancer patients.

Career achievements (selected):

Parker Institute for Cancer Immunotherapy, Bridge Fellow (2021)

Society for Immunotherapy of Cancer, Steven A. Rosenberg Scholars Award (2022)

Education and Training

BS, University of Michigan (Environmental Science), 2008

PhD, Northwestern University Feinberg School of Medicine (Immunology), 2016

Postdoctoral Fellowship, Stanford University School of Medicine (CAR-T cell engineering), 2021

Titles and Academic Titles

Assistant Professor of Pediatrics, Perelman School of Medicine, University of Pennsylvania

Professional Memberships

Society for Immunotherapy of Cancer

American Society of Hematology

American Association for Cancer Research

American Society of Gene and Cell Therapy

Professional Awards

American Heart Association Predoctoral Fellowship (2012)

Stanford Cellular and Molecular Immunobiology T32 Training Grant (2016)

First place award, Immuno-oncology Young Investigators’ Forum (2019)

First-author paper selected by Blood Advances as “Top Influential Article” (2020)

Parker Institute for Cancer Immunotherapy, Bridge Fellow (2021)

Society for Immunotherapy of Cancer, Steven A. Rosenberg Scholars Award (2022)

Publication Highlights

PubMed:
Weber EW, Parker KR, Sotillo E, Lynn RC, Anbunathan H, Lattin J, Good Z, Belk JA, Daniel B, Klysz D, Malipatlolla M, Xu P, Bashti M, Heitzeneder S, Labanieh L, Vandris P, Majzner RG, Qi Y, Sandor K, Chen LC, Prabhu S, Gentles AJ, Wandless TJ, Satpathy AT, Chang HY, Mackall CL. Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science. 2021 Apr; 372(6537). PMID: 33795428
Weber EW, Maus MV, Mackall CL. The emerging landscape of immune cell therapies. Cell. 2020 Apr; 181(1):46-62. PMID: 32243795
Weber EW, Lynn RC, Sotillo E, Lattin J, Xu P, Mackall CL. Pharmacologic control of CAR T cell function using Dasatinib. Blood Adv. 2019 Mar; 3(5):711-717. PMID: 30814055

Active Grants/Contracts

Society for Immunotherapy of Cancer Steven A. Rosenberg Scholar Award, Weber (PI), 2022-2024

Parker Institute for Cancer Immunotherapy Bridge Fellow Award, Weber (PI), 2021-2024