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Eugene Khandros, MD, PhD
Assistant Professor of Pediatrics
Dr. Eugene Khandros is a physician-scientist with a clinical and research focus on disorders of red blood cells and hemoglobin production.
Education and Training
BA, Columbia University (Biochemistry) 2005
PhD, Perelman School Of Medicine of the University Of Pennsylvania (Cell And Molecular Biology), 2011
MD, Perelman School Of Medicine of the University Of Pennsylvania, 2013
Residency, Morgan Stanley Children's Hospital of New York (Pediatrics), Columbia University, 2013-2016
Fellowship, Children’s Hospital of Philadelphia (Pediatric Hematology/Oncology), 2016-2019
Titles and Academic Titles
Assistant Professor of Pediatrics
Attending Physician
Professional Awards
Alpha Omega Alpha, 2012
Adolph J. Creskoff Prize, Perelman School of Medicine, University of Pennsylvania, 2012
NHLBI Medical Scientist Training Program Competitive Grant, 2009-2012
Predoctoral Training Grant in Genetics, Perelman School of Medicine, University of Pennsylvania, 2008-2009
Emily and Francis Botelho Prize for Excellence in Basic Science, Perelman School of Medicine, University of Pennsylvania, 2008
Publication Highlights
Lechauve C, Keith J, Khandros E, Fowler S, Mayberry K, Freiwan A, Thom CS, Delbini P, Romero EB, Zhang J, Motta I, Tillman H, Cappellini MD, Kundu M, Weiss MJ. The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia. Sci Transl Med. 2021 Aug; 11(506): eaav4881. PubMed PMID: 31434755
Khandros E, Blobel GA. Heterogeneity of fetal hemoglobin production in adult red blood cells. Curr Opin Hematol. 2021 Jan; 28(3): 164-170. PubMed PMID: 33631783
Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA. HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation. Blood Adv. 2020 Sep; 4(18): 4560-4572. PubMed PMID: 32956454
Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA. The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. Blood. 2020 Jun; 135(24): 2121-2132. PubMed PMID: 32299090
Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalik O, Giardine BM, Zhang Z, Keller CA, Hardison RC, Blobel GA. Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts. Blood. 2020 May; 135(22): 1957-1968. PubMed PMID: 32268371