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Advances the Research Institute’s commitment to the development of shared resources that facilitate interdisciplinary research through numerous Core facilities that service both laboratory and clinical research programs.
Dr. MacFarland's research focuses on syndromes that predispose to cancer development in children and adolescents. She has initiated several individual and collaborative research projects, working in pediatric polyposis syndromes and Li-Fraumeni syndrome. She is uncovering novel genomic drivers of disease and identifying biomarkers of cancer onset and progression.
Dr. Margaritis uses biochemical, molecular, and complex in vivo methodology within the field of coagulation to advance the understanding of molecular mechanisms involved in pro- and anti-coagulant reactions, and translate research for the treatment of coagulation defects.
Dr. Maris investigates the molecular and genetic mechanisms contributing to the development and progression of neuroblastoma, a common childhood cancer. He also aims to develop new molecular diagnostic tests and less toxic, targeted therapies to treat relapsed or refractory neuroblastoma, including a major effort in immunotherapy discovery and development.
Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.
Dr. Marsh's research program focuses on understanding how changes in brain development lead to epilepsy, intellectual disability, and autism. He combines molecular and physiological tools in mouse models to ask questions about the interaction of normal development with single gene mutations to determine how the brain responds to perturbations in development.
Dr. Mascarenhas is director of the Nutrition Support Service, section chief of nutrition in the Division of Gastroenterology and Nutrition, medical director of the Clinical Nutrition Department, and director of the Integrative Health Program. Her research interests involve 22q deletion syndrome, cystic fibrosis, nutrition, and integrative medicine.
Dr. Maude focuses on novel therapies for high-risk and relapsed pediatric acute lymphoblastic leukemia (ALL). She aims to identify new pediatric ALL treatments that are more effective, less toxic, and exhibit fewer side effects than existing cancer therapies.
Dr. Mautone's research focuses on assessment and treatment of attention-deficit/hyperactivity disorder. She has expertise in family-school-health system collaboration, classroom consultation, and integrated behavioral health in primary care settings. She has a special interest in increasing access to high-quality, culturally competent care for underserved children and families.
Dr. Mayne is an epidemiologist whose research focuses on preventing cardiovascular disease and promoting healthy behaviors in children and their families. She employs multilevel and longitudinal methods to study how factors at the individual, family, neighborhood, and policy level influence risk factor behaviors and cardiometabolic outcomes. She is also engaged in research to promote innovation in pediatric primary care.
Dr. McCormack investigates the intersection of neuroendocrinology and metabolism. Her translational research program involves two areas. The first involves studying those with genetic disorders, including primary mitochondrial diseases and Friedreich's ataxia, with characterized risk for diabetes mellitus. Second, Dr. McCormack focuses on brain disorders associated with excess weight gain, including brain tumor-related hypothalamic obesity syndrome and idiopathic intracranial hypertension.
Dr. Miller conducts developmentally informed behavioral research to examine the impact of parent-youth communication and decision making on health-related behaviors and outcomes. She aims to conduct research that facilitates youth involvement and empowerment in health-related decision making and enhances parent-youth-provider relationships.
Dr. Miller's research focuses on the diagnostic and classification issues most pressing to autism spectrum disorder (ASD) research, including differentiating ASD from other genetic and psychiatric conditions, diagnosis across the lifespan, and early identification and screening.
Dr. Mollen's research career has been focusing on using non traditional setting as sites for interventions to improve adolescent reproductive health. She founded and oversees a research program in Children's Hospital of Philadelphia's Emergency Department that provides sexual health education and HIV testing services, and explores intervention opportunities for increasing access to reproductive health services in the ED.
Dr. Monos is an internationally recognized expert on histocompatibility (HLA) molecules. His work covers a wide spectrum of HLA-related issues that pertain to both the molecular (structure/function) aspects of HLAs, as well as the genetics of the major histocompatibility complex, that includes the genes encoding the HLA molecules.
Dr. Mossé's research goal is to improve cure rates for the childhood cancer neuroblastoma by discovering the genetic basis of the disease and translating rational therapeutic opportunities to the clinic. She studies the contribution of DNA sequence variations and activation mutations of anaplastic lymphoma kinase (ALK) genes on the development and progression of both inherited and acquired forms of neuroblastoma.
Dr. Mostoufi-Moab's clinical and research program is focused on endocrine late effects after childhood cancer therapy. She has unique dual training in pediatric endocrinology and oncology with a master's degree in clinical epidemiology. The goal of her research program is to pursue a mechanistic understanding of metabolic and endocrine disorders that occur due to cancer therapy.
Dr. Muthu's research interest is in the area of cognitive informatics, with a focus on the refinement and application of cognitive engineering methods to improve health information technology safety and augment clinical decision-making.
The research conducted by Dr. Myers focuses on the identification and implementation of hospital-level factors that improve outcomes for seriously sick or injured children, as well as those who have time-sensitive and acute-care responsive disease processes.