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Dr. Ackermann studies diabetes (types 1 and 2) and congenital hyperinsulinism using mouse models, cell lines, and primary human tissue. She aims to identify novel pathways regulating beta cell insulin secretion, leading to innovative therapeutic strategies for these disorders. Current studies include in vivo mouse physiology, ex vivo human islet physiology, CRISPR-Cas9 gene editing, epigenetic modification, and single-cell functional genomics.
Dr. Adamson serves as chair of the international consortium Children's Oncology Group and on the National Cancer Advisory Board. In addition to his national and international leadership roles in pediatric oncology, Dr. Adamson maintains a dynamic research program on pediatric clinical-translational drug development, with a strong focus on childhood cancer drug development.
The founder and director of CHOP's Center for Fetal Diagnosis and Treatment, Dr. Adzick is an innovator in the field of fetal medicine, pursuing groundbreaking prenatal treatment for debilitating birth defects. He led the NIH-funded "Management of Myelomeningocele Study" (MOMS) at CHOP, a breakthrough research program that showed fetal surgery for spina bifida results in significantly improved outcomes.
Dr. Ahrens-Nicklas works to understand why patients with inherited biochemical disorders often suffer severe, untreatable neurologic and cardiac symptoms. She strives to elucidate the link between biochemistry and network excitability, in order to drive new approaches to therapy.
Dr. Akers is an adolescent gynecologist and her research focuses on improving reproductive health outcomes among adolescent women by reducing teen pregnancy, and reducing sexually transmitted infection rates by increasing adolescents’ access to high quality reproductive health services.
The research interests of Dr. Allen include lung function testing in children, adolescents, and infants; developmental chest wall physiology; pulmonary complications of sickle cell disease; and complications of cystic fibrosis.
Dr. Amaral's research is focused on kidney transplantation with particular interests in reducing treatment burden for adolescents and young adults — from designing studies to make daily medication regimens easier to diagnosing transplant injury earlier using innovative, noninvasive approaches.
Dr. Anari has research interests in pediatric chest wall and spinal deformities. His current research projects include understanding how children respond overall to chest wall surgery in thoracic insufficiency. He's working to identify which patients with early-onset scoliosis are at risk for unplanned surgery in an attempt to limit anesthesia exposure to the developing brain.
Dr. Anderson’s research interests focus on the molecular and cellular mechanisms that govern the development of the mammalian forebrain. In his research on the development of the cerebral cortex, he is particularly interested in understanding the molecular underpinnings behind the fate determination and axon targeting of subclasses of GABAergic interneurons implicated in the neuropathology of schizophrenia.
As vice chair of clinical research in the Department of Radiology, Dr. Andronikou oversees a growing translational and clinical research program that is broadly related to and impacts nearly every pediatric subspecialty. This program includes interventional radiology, cardiovascular, lymphatic imaging, pulmonary imaging, and oncology, among many others.
As a bioengineer, Dr. Arbogast's research focuses on pediatric injury biomechanics, injury causation and the effectiveness of safety products for children with a concentration in the safety of children and youth in motor vehicle crashes as well as pediatric concussion.
Dr. Argon investigates the unfolded protein response (UPR) , an essential signaling network that determines life or death of stressed cells and tissues. The IRE1 sensor of UPR responds to metabolic stress through four distinct activities and he focuses on determining which stress condition induces each activity and how they are integrated to enable the cells to cope with stress.
Dr. Arkader is one of few orthopedic surgeons in the country with formal training in both pediatric orthopedics and orthopedic oncology. He has a special interest in complex trauma and limb deformities, and specializes in external fixation methods and other minimally invasive techniques for limb preservation and equalization benefiting growing children.
The development of gene-based strategies for the treatment of bleeding and thrombotic diseases is at the heart of research by Dr. Arruda. Working collaboratively, Dr. Arruda and his colleagues have carried out early-phase clinical studies on adeno-associated viral vectors for the treatment of severe hemophilia B.