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E-mail
johna3 [at] email.chop.edu
Phone
Location - People View
Room 907C, 9th floor

3615 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Audrey R. Odom John, MD, PhD
Audrey R. Odom John, MD, PhD
Chief, Division of Infectious Diseases

Dr. John studies the malaria parasite, Plasmodium falciparum, to understand its basic molecular and cellular biology and functions of its specific metabolic pathways — what the parasite needs to make and why it needs to make it — to identify new antimalarial drug targets and develop new diagnostics.

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Bio

A physician-scientist, Dr. John’s NIH-funded research focuses on Plasmodium falciparum malaria parasites, with a particular interest in targeting parasite metabolism to identify novel targets for drug development and noninvasive approaches to diagnosis. New drugs are urgently needed to treat malaria, which causes nearly 500,000 deaths per year, mostly in very young children. Dr. John is an investigator in the Pathogenesis of Infectious Diseases of the Burroughs Welcome Fund. She has received numerous accolades, including awards from the American Chemical Society, March of Dimes, and most recently the IDea Incubator Grand Prize from the Infectious Diseases Society of America.

Education and Training

BS, Duke University, (Biology, minor Chemistry), 1996

PhD, Duke University School of Medicine, (Biochemistry), 2002

MD, Duke University School of Medicine, 2002

Pediatric Residency (Special Alternative Pathway), University of Washington, 2003-2005 

Pediatric Infectious Diseases Fellowship, University of Washington, 2005-2008

Titles and Academic Titles

Chief, Division of Infectious Diseases

Professional Memberships

Pediatric Infectious Diseases Society

Infectious Diseases Society of America

American Society of Microbiology

American Society of Tropical Medicine and Hygiene

Professional Awards

Doris Duke Charitable Foundation, Clinical Scientist Development Award, 2010

Innovator Award, St. Louis Academy of Science, 2012

Outstanding Commitment to Teaching Award, Washington University School of Medicine, Department of Pediatrics, 2013

Basil O’Connor Starter Scholar Award, March of Dimes, 2013

Election, Society for Pediatric Research, 2014

Grand challenge winner and invited speaker, TEDxKC, 2015

Emerging Leader Award, Duke University School of Medicine Alumni Association, 2016

Young Investigator Award, American Chemical Society – Infectious Diseases,
2016

Investigator in the Pathogenesis of Infectious Diseases, Burroughs Wellcome Fund, 2016

IDea Incubator Grand Prize winner, Infectious Diseases Society of America (IDSA), 2018

Publication Highlights

Guggisberg AM, Frasse PM, Jezewski AJ, Kafai NM, Gandhi AY, Erlinger SJ, Odom John AR. Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites. mBio. 2018 Nov; pii: e01193-18. doi: 10.1128/mBio.01193-18. PMID: 30425143; PMCID: PMC6234871
Schaber CL, Katta N, Bollinger LB, Mwale M, Mlotha-Mitole R, Trehan I, Raman B, Odom John AR. Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants. J Infect Dis. 2018 Apr; 217(10):1553-1560. doi: 10.1093/infdis/jiy072. PMID: 29415208
Guggisberg AM, Sundararaman SA, Lanaspa M, Moraleda C, González R, Mayor A, Cisteró P, Hutchinson D, Kremsner PG, Hahn BH, Bassat Q, Odom AR. Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin. J Infect Dis. 2016 Oct; 214(7):1085-91. doi: 10.1093/infdis/jiw304. Epub 2016 Jul 20. PMID: 27443612, PMCID: PMC5021231
Kelly M, Su CY, Schaber C, Crowley JR, Hsu FF, Carlson JR, Odom AR. Malaria parasites produce volatile mosquito attractants. mBio. 2015 Mar; 6(2). pii: e00235-15. doi: 10.1128/mBio.00235-15. PMID: 25805727, PMCID: PMC4453533
Guggisberg AM, Park J, Edwards RL, Kelly ML, Hodge DM, Tolia NH*, Odom AR*. A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun. 2014 Jul; 5:4467. doi: 10.1038/ncomms5467. PMID: 25058848, PMCID: PMC4112465

Links of Interest