PennCHOP Microbiome Program
The PennCHOP Microbiome Program supports research across a wide spectrum of topics, with the goal of devising methods for improving human health by manipulating microbial populations. Today, the microbiome is known to influence the course of numerous diseases, such as heart disease, cancer, diabetes, inflammatory bowel disease, autism, and obesity, to name a few. Studies are now expanding to link up microbiome research with myriad diverse areas of basic, translational, and clinical research.
Within the PennCHOP Microbiome Program is The CHOP Microbiome Center, the sequencing and analytical resource for the Program. The Center supports the planning of microbiome projects, DNA purification, library preparation, high throughput sequencing, and bioinformatic analysis of the output.
Microbiome research at Penn and CHOP includes analysis of multiple human body sites including gut, airway, and skin. Microbiome studies also have been carried out extensively working with animal models, including germ free (gnotobiotic) mice. Additional ongoing projects seek to translate insights in microbiome analytical methods to clinical diagnosis.
Research Project Highlights
Examples of ongoing microbe research projects include:
- Annual PennCHOP Microbiome Pilot & Feasibility Projects
- Transfer: Dissecting the interplay of MCH/HLA loci, the microbiota and autoimmune diabetes
- Longitudinal analysis of respiratory tract microbiome change and sequence-based infection diagnosis during mechanical ventilation
- Role of Bacterial Urease in Host and Gut Microbiota Amino Acid Metabolism