PCEN Programs

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Enrichment Program

The Enrichment Program promotes innovative multidisciplinary research in pediatric kidney disease through promoting involvement by students and residents, with programs including a Summer Scholars Program for students, and Travel Awards to national meetings for residents.

Pilot and Feasibility Program

The Pilot and Feasibility Program aims to break down barriers to implementing clinical trials in childhood kidney disease. Each year, the PCEN seeks applications to support at least one pilot and feasibility research project with funding of up to $50,000 per project.

CHOP's Pediatric Center of Excellence in Nephrology (CHOP PCEN) aims to break down barriers to implementing clinical trials in childhood kidney disease. Each year the Center seeks applications to support at least one pilot and feasibility research project. Maximum funding is $50,000 for one year.

The Call for Pilot/Feasibility Proposals for Clinical Trials in Pediatric Kidney Disease is currently open.

Call for Pilot/Feasibility Proposals for Clinical Trials in Pediatric Kidney Disease

Applications must include human subjects research in pediatric nephrology. Basic science research or diseases outside pediatric kidney disease are not accepted. Proposals must focus on research that will directly lead to clinical trials in pediatric nephrology and may utilize one of the CHOP PCEN Cores, including our collaboration with the Chronic Kidney Disease in Children (CKiD) study. The Administrative Core will facilitate collaborations with the CKiD study. The pilot application itself does not have to be a clinical trial.

Eligibility

Early-stage investigators, new investigators, or established investigators not previously involved in pediatric nephrology research are invited to apply. Research topics should be human subjects research related to the prevention, treatment, or progression of kidney disease in children and its associated morbidities, and identifying novel strategies for subsequent clinical trials.

Key Dates

  • Intent to apply surveys are due by Friday, October 27, 2023 at 5:00 p.m. EST.
  • Invitations to submit Full Applications will be issued by November 13, 2023.
  • Full Applications are due by Friday, December 15, 2023 at 5:00 p.m. EST.
  • Awards will be announced in March 2024.

The funding period will be April 1, 2024 to May 31, 2025.

How to Apply

More information about application guidelines is available in the Call for Proposals. All applications should be submitted electronically to our program email, [email protected], as PDFs.

Application or Funding Questions

Please contact [email protected] with questions.

2018 Pilot Projects

Principal Investigator:Amy Kogon, MD, MPH, assistant professor, CHOP
Project Title: Determinants of Obesity in Pediatric CKD and the Links to Cardiovascular Outcomes
Core: Clinical Phenotyping

Principal Investigators: Meredith Atkinson, MD, MHS, associate professor of Pediatrics, Johns Hopkins University School of Medicine, and Scott Wenderfer, MD, PhD, associated professor, Baylor College of Medicine
Project Title: Learning Health Systems for Pediatric Lupus and Lupus Nephritis Research
Core: Learning Health System

Two additional projects were partially supported with seed funding.

Principal Investigator: Oleh Akchurin, MD, PhD, assistant professor, Weill Cornell Medicine
Project Title: Pilot Clinical Trial of Oral Iron Therapy in Pediatric CKD
Core: Clinical Phenotyping

Principal Investigator: Abdulla Ehlayel, MD, clinical assistant professor, LSU School of Medicine; former CHOP Nephrology Fellow
Project Title: Volume Assessment in Dialysis Patients using Ultrasound, Anthropometric Measurements and Bioimpedance
Core: Clinical Phenotyping

2019 Pilot Projects

Principal Investigator: Erum Hartung, MD, MTR, assistant professor, CHOP
Project Title: Develop and Validate a Computable Phenotype for ARPKD
Core: Learning Health System Core

Three additional projects were partially supported with seed funding through the Pilot and Feasibility Program.

Principal Investigators: Hillarey Stone, DO (Fellow, University of Cincinnati), Edward Nehus, MD, assistant professor, University of Cinncinati, and Mark Mitsnefes, MD, professor, University of Cinncinati
Project Title: Treatment Practices and Outcomes in Children with IgA Vasculitis with Nephritis
Core: Learning Health System Core

Principal Investigator: Rebecca Ruebner, MD, assistant professor, Johns Hopkins University
Project Title: Pubertal Effects on Kidney Disease Progression and Cardiovascular Disease in Children with CKD
Core: Clinical Phenotyping Core

2020 Pilot Projects

Principal Investigator: Joyce Samuel, MD, assistant professor, McGovern Medical School at University of Texas Health Science Center
Project Title: Feasibility of N-of-1 Trials in Children with Hypertension and Chronic Kidney Disease (NICHE-CKD) study
Core: Learning Health System Core

Principal Investigator: Vikas Dharnidharka, MD, MPH, professor, Washington university in St. Louis School of Medicine
Project Title: Comparative effectiveness of treatments for recurrent focal segmental glomerulosclerosis in pediatric kidney transplantation
Core: Learning Health System Core

2021 Pilot Projects

Principal Investigator: Daryl McLeod, MD, MPH, and Brian Becknell, MD, PhD, at Nationwide Children’s Hospital
Project Title: Proteomic Analysis to Predict Kidney Disease Progression in Children with Congenital Urinary Tract Obstruction
Core: Administration Core (CKiD Collaboration)

2023 Pilot Projects

Principal Investigator: Christian Hanna, MD, MS
Project Title: Assessing the Accuracy of Measuring Total Kidney Volume and Characterizing Kidney Cysts in Children with Autosomal Dominant Polycystic Kidney Disease Using Three-Dimensional Ultrasound and Deep Learning Approaches
Core: N/A

Principal Investigator: Rebecca Levy, MBBCh, BAO, MSc
Project Title: Variation in the Care of Adolescents and Young Adults with Chronic Kidney Disease between Internal Medicine and Pediatric Nephrologists
Core: Learning Health System Core

2024 Pilot Projects

Principal Investigator: Shruthi Mohan, MD
Project Title: Combination of Bioelectrical Impedance Analysis and NT-pro BNP to assess fluid status in children undergoing continuous renal replacement therapy: A prospective observational comparative study
Core: N/A

Principal Investigator: Ashton Chen, DO
Project Title: Impact of social drivers of health on pediatric kidney transplant outcomes
Core: Learning Health System Core

Any publications or presentations that are the direct result of this funding must acknowledge the grant support:
Research reported in this publication was funded by The Children's Hospital of Philadelphia Pediatric Center of Excellence in Nephrology and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award number P50DK114786. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Additionally, please submit an electronic copy of publications supported by CHOP PCEN funding to  Hannah MacLean.