Pediatric Center of Excellence in Nephrology



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Children's Hospital of Philadelphia established the Pediatric Center of Excellence in Nephrology (PCEN) with funding from the National Institute of Diabetes and Digestive and Kidney Diseases to promote and develop clinical trial research with a focus on nephrology. CHOP PCEN's mission is to increase efficiency and reduce barriers to collaborative clinical trials by serving as a widely available resource to all clinicians, researchers, and investigators helping children with kidney disease. Its Cores and Programs aim to increase awareness of nephrology research, the impact of the research, and the robustness of its clinical trials.


Research Highlights

Bone Quality and Vascular Health in Adolescents with Urinary Stone Disease

Increasingly recognized as a chronic systemic disorder with skeletal and vascular morbidity, urinary stone disease is increasing disproportionately among adolescents, making it critical to understand its impact on bone and vascular health in this population. Read more.

Derivation and Validation of Imaging Biomarkers for CKD Progression

Biomarkers are needed that can identify children with congenital anomalies of the kidneys and urinary tract early in life who are at high risk of future chronic kidney disease progression and help guide clinical trials. Read more.