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Find information and resources about the Research Institute's COVID-19 response
Find information and resources about the Research Institute's COVID-19 response
Bone disorders exact a considerable toll on human health in both children and adults. The Long Lab seeks to understand the fundamental mechanisms underlying both normal skeletal development and the pathophysiology of bone diseases.
Through mouse genetic studies, the Long Lab has defined specific functions of key developmental pathways such as Hedgehog, Wnt, and Notch signaling in bone development and homeostasis. Biochemical studies conducted in the lab have led to the discovery that developmental signals reprogram cellular metabolism to change cell fate.
Current research in the lab includes studies of skeletal stem cells and progenitors, metabolic regulation of skeletal cells, and the integration of bone and whole-body metabolism. The lab is testing the hypothesis that dysregulation of glucose metabolism is a root cause for skeletal disorders associated with diabetes and aging.
Investigator
Bone disorders exact a considerable toll on human health in both children and adults. Dr. Long seeks to understand the fundamental mechanisms underlying both normal skeletal development and the pathophysiology of bone diseases. His current research includes studies of skeletal stem cells and progenitors, metabolic regulation of bone cells, and the integration of bone and whole-body metabolism.