LEOPARDS Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

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The study goal is to risk stratify pediatric (Acute Respiratory Distress Syndrome) ARDS patients and to identify sub-phenotypes with shared biology in order to appropriately target therapies in future trials. Specifically, the study aims to:

  • Aim 1: Validate and refine PARDSEVERE, a published protein biomarker-based pediatric ARDS risk stratification tool
  • Aim 2: Stratify pediatric ARDS into sub-phenotypes using a known 100-gene expression-based classifier to group subjects according to shared underlying biology
  • Aim 3: Identify de novo sub-phenotypes in pediatric ARDS using biomarkers and whole genome transcriptomics of peripheral blood

Eligibility & Criteria

IRB #:
19-016271
Official Title:
Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome
Study Phase:
Not Applicable
Eligible Age Range:
1 Months - 17.5 Years
Gender:
All
Study Categories: