Hamilton Laboratory

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The Hamilton Lab specializes in understanding mechanisms regulating gut homeostasis in health and disease, with a specific interest in intestine and colon epithelial cell responses to damage and inflammation. The lab employs in vivo models and primary, three-dimensional enteroid and colonoid cultures from mice and humans to understand the molecular basis of intestinal regeneration, inflammatory bowel disease (IBD), and colorectal cancer. Within these contexts, the Hamilton Lab is interested in how RNA-binding proteins impart global, post-transcriptional regulation of key pathways in normal physiology and pathophysiology.

Project Highlights

  • Dissecting regulation of the autophagy pathway by the RNA binding protein, IMP1
  • Evaluating specific inflammatory factors regulating the RNA binding protein, IMP1, and response to experimental colitis
  • Understanding RNA binding protein "regulons" in adult inflammatory bowel disease
  • Evaluating novel pathways regulated by IMP1 in pediatric, VEO (Very Early Onset)-IBD
  • Evaluating the role of RNA binding protein, IMP1, overexpression in amplifying or suppressing key oncogenes in inflammation-associated colorectal cancer
Leader

Kathryn E. Hamilton, PhD

Investigator
Dr. Hamilton studies intestinal epithelial cells and how they help maintain human health. Although there is a great deal understood about how these cells function, little is known about how they behave during disease. Dr. Hamilton focuses on defining new mechanisms in regenerative medicine, inflammatory bowel disease, and colorectal cancer.