In This Section

Engineering Technologies to Interrogate and Direct Cellular Interactions for Cell-Based Therapy

AddtoAny
Share:

WATCH THIS PAGE

Subscribe to be notified of changes or updates to this page.

16 + 3 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Date:
Mar 17, 2021 ‐ 2:00 pm
End Date/Time-NEW

Join us for a Cell and Gene Therapy Center Special Seminar:

Engineering Technologies to Interrogate and Direct Cellular Interactions for Cell-Based Therapy

Faculty candidate:

Suman Bose, PhD
NIH NIBIB K99 Pathway to Independence Fellow
Research Scientist
Massachusetts Institute of Technology
Anderson and Langer Lab

Abstract:

Cellular interactions are central to several biological processes, and understanding and controlling how cells interact is critical for designing effective cell-based therapies. In this talk, Dr. Bose will discuss how precision-engineered devices can be designed to interrogate, manipulate, and control cells in vitro and in vivo.

First, he will describe development of a microengineered implant that can protect and maintain xenogeneic cells secreting therapeutic factors inside immunocompetent hosts. Dr. Bose will show how device design can be used to direct immune interactions with the transplant and enable long-term viability of the xenograft. These implants act as living drug factories inside the body, and Dr. Bose and his colleagues are exploring the potential of this platform to treat chronic diseases such as blood disorders, diabetes, and liver failure.

Next, he will present his team's most recent work on creating novel platforms for sequencing non-coding RNAs in single cells. They have developed a high-throughput microfluidic device that can rapidly enrich and barcode microRNAs from single cells and process them for analysis through next-generation sequencing. Dr. Bose will discuss the potential of this technology as a tool for detecting diseases and to study cell function. He will conclude with a high-level overview of problems his future lab is interested in and his team's interdisciplinary approach to solving them.

Host:

Beverly Davidson, PhD
Please e-mail webber@chop.eduif you would like to meet with the speaker.

This event requires registration in order to add it to your calendar.
Event Type: