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Developing Better Cancer Vaccines

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Date:
Jun 4, 2021 ‐ 12:00 pm
End Date/Time-NEW
Location - People View

The Center for Computational and Genomic Medicine Presents:

Developing Better Cancer Vaccines

Speaker:

Catherine J. Wu, M.D.
Professor of Medicine
Dana-Farber Cancer Institute and Harvard Medical School
Chief, Division of Stem Cell Transplantation and Cellular Therapies
Institute Member, Broad Institute of Harvard and MIT
Boston, MA

About Dr. Wu's Research:

Multiple lines of evidence have convincingly demonstrated tumor neoantigens as an important class of immunogenic tumor antigens, and have motivated the development of personalized cancer neoantigen targeting approaches. Neoantigens arise from amino acid changes encoded by somatic mutations in the tumor cell and have the potential to bind to and be presented by personal HLA molecules. As a field, we have now successfully moved beyond the first wave proof-of-concept studies that have demonstrated the safety, feasibility and high immunogenicity of these personalized vaccines. An imperative now is to address the challenges of discovering and optimizing the selection of antigens to target, the delivery approach, and extending this promising approach to a broader array of cancer settings.

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Add to Calendar 2021-06-04 12:00:00 2021-06-04 13:00:00 Developing Better Cancer Vaccines The Center for Computational and Genomic Medicine Presents: Developing Better Cancer Vaccines Speaker: Catherine J. Wu, M.D. Professor of Medicine Dana-Farber Cancer Institute and Harvard Medical School Chief, Division of Stem Cell Transplantation and Cellular Therapies Institute Member, Broad Institute of Harvard and MIT Boston, MA About Dr. Wu's Research: Multiple lines of evidence have convincingly demonstrated tumor neoantigens as an important class of immunogenic tumor antigens, and have motivated the development of personalized cancer neoantigen targeting approaches. Neoantigens arise from amino acid changes encoded by somatic mutations in the tumor cell and have the potential to bind to and be presented by personal HLA molecules. As a field, we have now successfully moved beyond the first wave proof-of-concept studies that have demonstrated the safety, feasibility and high immunogenicity of these personalized vaccines. An imperative now is to address the challenges of discovering and optimizing the selection of antigens to target, the delivery approach, and extending this promising approach to a broader array of cancer settings. Join from a PC, Mac, iPad, iPhone or Android device via Zoom Passcode: 900035 Or iPhone one-tap: +13126266799,,82241944346#,,,,*900035# US (Chicago) +16465588656,,82241944346#,,,,*900035# US (New York) Or join by phone: Dial(for higher quality, dial a number based on your current location): US: +1 312 626 6799 or +1 646 558 8656 or +1 301 715 8592 or +1 346 248 7799 or +1 669 900 9128 or +1 253 215 8782 Webinar ID: 822 4194 4346 Passcode: 900035 International numbers available: https://us02web.zoom.us/u/kcea2RDz14 - colest@chop.edu America/New_York public