The Eisch Lab includes neuroscientists interested in how molecular and cellular changes, such as altered number of new neurons in the hippocampal dentate gyrus — a brain region important for learning/memory and regulation of anxiety and the stress response — influence both normal and abnormal behavior and cognitive function. The lab is interested in how developmental and adult neurogenesis in particular, and dentate gyrus plasticity in general, contribute to maladaptive dentate gyrus function with relevance to developmental, psychiatric, and neurological disorders. The lab's basic work in animal models lays the essential groundwork for identifying and developing new strategies for preventing and treating human disorders, particularly those whose underpinnings are linked to early life experiences.
Current Eisch Lab projects span genetic, molecular, cellular, circuit, and functional/behavioral levels, and are funded by NASA and NIH (both the National Institute on Drug Abuse and National Institute on Mental Health).
Dr. Eisch is a neuroscientist interested in how molecular, cellular, and circuit changes—particularly in the limbic system—influence motivated behavior and cognition. She is specifically interested in how neuroplasticity in the hippocampal dentate gyrus contributes to both normal and pathological function with relevance to depression and addiction.