Division of Endocrinology and Diabetes Research Studies

The purpose of this research study is to examine and understand the various mechanisms that contribute to Cystic Fibrosis Related Diabetes and gain a better understanding of potential means to treat Cystic Fibrosis Related Diabetes.

The goals of this research study are to find out how having COVID-19 recently affects blood sugar, inflammation, and insulin in people with type 1 and type 2 diabetes.

This study is a 2 period, open label study that will evaluate the safety and efficacy of dasiglucagon in children between the ages of 3 months and 12 years.

This study is a randomized, double-blind, placebo-controlled study that will evaluate the safety and efficacy of dasiglucagon in children between the ages of 7 days and 12 months who have congenital hyperinsulinism.

The goal of this study is to identify a safe dosing regimen for siplizumab in participants with type 1 diabetes.

This study aims to design and optimize the Hypothyroidism Treatment Satisfaction Questionnaire (ThyTSQ) for measuring treatment satisfaction. 

The DISCOVERY Study is a new, national effort to learn about the causes of type 2 diabetes in children.

Our team at the Congenital Hyperinsulinism Center at CHOP is working on a research study to determine whether an experimental gene therapy product, DTX401, is safe and effective in people with glycogen storage disease type Ia (GSDIa)

The purpose of this research study is to test how people with cystic fibrosis process sugar and learn more about their risk of developing cystic fibrosis-related diabetes. 

You are invited to take part in a voluntary research trial because you have type 2 diabetes and are between the ages of 10 and 17 years.

The main goal of this study is to learn more from patients and their families about potential barriers of exercise and receptiveness to various interventional trial designs in survivors of childhood craniopharyngioma.

The goal of this Phase 2 study is to assess safety and efficacy of frexalimab to preserve β-cell function in participants with newly diagnosed type 1 diabetes (T1D).

The purpose of this study is to look at the safety and tolerability (how well you will react) of the study drug (HM15136) and to determine if it is effective for the treatment of Congenital Hyperinsulinism (HI).

A research study about bone health in children and adolescents at high risk of suffering a broken bone.

Researchers at CHOP are recruiting patients diagnosed with either acute leukemia (myeloid, lymphoid), myelodysplastic syndromes, or aplastic anemia and treated with allogeneic hematopoietic cell transplantation (HCT) within the past 6-48 months.

The purpose of this research study is to find out if intranasal oxytocin (the hormone oxytocin, delivered through a nasal spray solution) will help with easy weight gain in children, adolescents, and adults with brain tumors and hypothalamic obesity syndrome.

This study wants to know about the problems that Black or African American teenagers with type 1 diabetes (T1D) and their families face.

This study will evaluate the safety and effectiveness of the MiniMed 780G insulin pump system used in combination with the DS5 CGM in type 1 diabetic pediatric participants in a home setting.

The purpose of this research study is to test and adapt new techniques for performing magnetic resonance imaging (MRI). MRI provides pictures of the inside of the body and information about chemicals the body makes.

Our team has partnered with Moderna on a clinical trial for patients with glycogen storage disease type 1a (GSD1a).

The purpose of the study is to determine changes in lactate and creatine in calf muscle of healthy adult volunteers.

The purpose of this research study is to learn more about Graves' disease and PTC/Hypothyroidism, how it effects brain function and brain function changes after starting medical treatment.

We are trying to learn more about the ways in which adolescents (12-17 years) are involved in decision making related to their chronic condition.

The purpose of this study is to evaluate the safety and pharmacokinetics (drug levels in the blood) of teplizumab in children less than 8 years old.

Congenital Hyperinsulinism is the most common cause of low blood sugar (hypoglycemia) in infants and children. Infants who are born with this problem have low blood sugar, which can cause seizures or brain damage.

The Congenital Hyperinsulinism Center at the Children's Hospital of Philadelphia is working on a research study to better understand how people with hyperinsulinism may have different blood sugar responses to certain tests (like fasting or drinking a high-protein shake) when compared to people without hyperinsulinism.

The purpose of this study is to evaluate how safe and effective the drug Qsymia (Phentermine/Topiramate of Ph/T) is for children, adolescents, and young adults with hypothalamic obesity.

PRONTO-PEDS will test if a ultra-fast insulin product given before or immediately after meals improves glycemic control in children and teens with type 1 diabetes.

Our team is working on a study to better understand neurological problems, including seizures and developmental delays, that occur in children with hyperinsulinism, including HI/HA syndrome, and type 1 diabetes mellitus.

This study is to better understand neurological problems, including seizures and developmental delays, that occur in many individuals with HI/HA syndrome.

Down syndrome can make it easier for kids and teens to become overweight.

The goal of the trial is to test the study drug safety, how your body processes the drug, how the drug affects your body, and see if it can increase your blood sugar.

The purpose of this study is to find out if an investigational drug called setmelanotide (RM-493) can help control body weight in people with certain genetic modifications in their genes that play a key role in the regulation of body weight.

The purpose of this study is to find out if an investigational drug called setmelanotide (RM-493) can help control body weight in people with certain genetic modifications in their genes that play a key role in the regulation of body weight.

The purpose of this study is to look at growth using a novel technique called diffusion tensor imaging (DTI) of the  growth plate in the knee. 

This is a study that investigates whether an IV medication (teplizumab) will slow or halt the progression of type 1 diabetes in children and adolescents (ages 8 - 17 years).

We are currently enrolling adolescents ages 15-21 of South Asian ancestry, African American ancestry, and European American or "White" ancestry.

The purpose of this study is to examine CHOP's experience with patients ages 0 to 19 years old who have already undergone or will be undergoing total thyroidectomy (TTx) and/or completion thyroidectomy performed at the Thyroid Center at CHOP.

Insulin therapy, commonly given as multiple daily injection therapy, is the only recommended treatment for Cystic Fibrosis Related Diabetes (CFRD).

Our team is working on a study to see if children with HI/HA Syndrome tolerate Vitamin E supplementation.