DBHi Translational Informatics Resources

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Biorepository Portal Toolkit

Designed with the modern biorepository in mind, the Biorepository Toolkit integrates key system components in a user-friendly interface to protect subject privacy, asynchronously collect data, and deeply annotate growing institutional specimen, data, and genomic repositories by integrating familiar tools.

The Biorepository Portal (BRP) is a federated web application originally designed to support longitudinal biospecimen collection activities. Using HTTP protocols, it interfaces with downstream data systems, including REDCap and Thermo Fisher Scientific's Nautilus LIMS, to provide a single unified interface for data collection and update activities. An electronic Honest Broker (eHB) ensures longitudinal data collection is performed in a manner compliant with NCI Best Practices for Biospecimen Resources.

The Department of Biomedical and Health Informatics developed an open-source informatics infrastructure to support data-intensive longitudinal biorepository studies. Benefits of using the BRP Toolkit include:

  • De-identification and re-identification of subjects on-the-fly
  • Creation and addition of records in multiple research systems to ensure patient privacy
  • A longitudinally updated specimen and data resource that enables more flexible non-human subjects research

The design of this integrated application set serves a two-fold process: integrating data on the way in and on the way out. Therefore, the applications support study management/operations and data query/scientific data integration. The toolkit integrates fully with REDCap and our enterprise LIMS for study data management. For data discovery, it integrates the Harvest Data Discovery Platform where the Portal and Honest Broker components of the toolkit broker data needs across systems and use cases.

View the Biorepository Portal Toolkit.

Electronic Honest Broker

CHOP uses an electronic Honest Broker (eHB) to facilitate secure linking of clinical, biological, research, and operational data across CHOP’s research groups. This additional layer offers researchers flexibility in using data collected from electronic health records, registries, repositories, and images while providing protection to the individuals whose data are being used for research. Use of the Honest Broker must be listed on research study protocols. By removing all links to individually identifiable data, the Honest Broker can enable secondary use of the research data without need for IRB protocol.

See additional information about CHOP’s Honest Broker policy.