Center for Applied Genomics


The Center for Applied Genomics (CAG) at Children's Hospital is one of the largest genetics research programs in the world with the primary goal of translating basic research findings into medical innovations for use at a patient's bedside. Its work and discoveries are propelled by its mission to develop new and better ways to diagnose and treat children affected by rare and complex medical disorders.

Since 2006, CAG's innovative and dynamic program has led to the discovery of the genetic causes for some of the most prevalent and devastating diseases of childhood including asthma, autism, diabetes, epilepsy, obesity, schizophrenia, pediatric cancer, and a range of rare diseases. These breakthroughs are steps along the path to the Center's ultimate goal: developing new diagnostic tests to guide physicians to the most appropriate therapies for their patients.

Not only is CAG one of the world's largest genetics research programs, but it is the only center at a pediatric hospital to have established a large-scale biobank with access to hundred's of thousands of multiple different sample types and state-of-the-art high-throughput genomics technologies. The center currently has more than 50 active disease projects – both internally and in collaboration with hundreds of researchers in North America, Europe, Australia and Asia. Its unique resources allow for the performance of large-scale human genotyping and sequencing studies: to date, CAG has analyzed the genetic data from more than 500,000 individuals.