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The Blobel Lab bridges molecular biology, biochemistry, and animal models to better understand the mechanisms of epigenetic memory and the nuclear architecture and genetic and epigenetic control of gene expression.
Specifically, the lab team examines how genetic regulatory elements are organized spatially within the nucleus and how transcription programs are epigenetically transmitted through mitosis to maintain lineage identity. This work spans basic science to preclinical studies on blood diseases. In addition, the Blobel Lab is developing genome and epigenome editing tools for the treatment of blood diseases.
One of the gene clusters the lab focuses on is the beta-globin locus and its associated diseases, such as sickle cell disease and thalassemia.
Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.