Anderson Laboratory

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The focus of the Anderson Laboratory centers on the molecular and cellular mechanisms involved in the development of the mammalian forebrain as it relates to neuropsychiatric disease. The lab is specifically interested in the fate determination of key subclasses of cortical inhibitory interneurons.

The dynamic research program in the Anderson Lab currently focuses on the generation of GABAergic interneurons from human stem cells; changes in synaptophagy in HIV-infected microglia; the identification of genetic risk and resilience cofactors for psychosis in 22q11.2 deletion syndrome; mitochondria deficits in HiPSC-derived neurons from 22q11.2DS + SZ patients; mitochondria, hypoxia, and cortical interneuron development; and the treatment/prevention of epilepsy using stem cell-derived cerebral cortical interneuron progenitors.

The lab employs mouse genetics, forebrain slice, and dissociated culture techniques, as well as mouse and human embryonic stem cells in cell culture and transplantation experiments in its study of the development of the cerebral cortex.

Project Highlights

Current projects in the lab include:

  • Acceleration of the maturation for human stem cell-derived neurons by reversible activation of mTOR signaling
  • Use of stem cell-derived inhibitory interneurons transplants to correct circuit pathology and abnormal social behaviors in a mouse model of Dravet's syndrome autism
  • Mitochondrial deficits in iPS-derived neurons from patients with schizophrenia and the 22q11 deletion syndrome
Leader

Stewart A. Anderson, MD

Director of Research, Department of Child and Adolescent Psychiatry and Behavioral Services
Dr. Anderson’s research interests focus on the molecular and cellular mechanisms that govern the development of the mammalian forebrain. In his research on the development of the cerebral cortex, he is particularly interested in understanding the molecular underpinnings behind the fate determination and axon targeting of subclasses of GABAergic interneurons implicated in the neuropathology of schizophrenia.