- 1922
- 1923
- 1924
- 1936
- 1940
- 1927
- 1937
- 1931
- 1932
- 1930
- 1940
- 1935
- 1936
- 1943
- 1946
- 1946
- 1956
- 1954
- 1963
- 1965
- 1966
- 1967
- 1971
- 1972
- 1973
- 1974
- 1983
- 1988
- 1989
- 1992
- 1995
- 1995
- 1997
- 1999
- 1997
- 2006
- 2010
- 2012
- 2015
- 2016
- 2018
- 2018
- 2019
- 2021
- 2021
- 2022
- 2022
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1922
1922
First Research Laboratory Established
Dr. Joseph Stokes Jr. worked in the first research laboratory at CHOP located in a small room in the hospital’s basement with one centrifuge.
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1936
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1936
1936
New Incubator Invented
Dr. Charles Chapple invented the first environmentally stable infant incubator.
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1937
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1930s
Late 1930s
Research Study Supported Homogenized Milk for Infants
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During the 1930s, Dr. Irving Wolman and Dr. Bernard Spur completed the initial study on the use of easily digestible homogenized milk for infants, which led to its public acceptance.
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1940
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1940
1940
Dr. T. McNair Scott Appointed First Director of Research
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While Dr. T. McNair Scott’s research focused on viruses, he was recognized by his flying coattails en route to meetings and was kindly known as “McMeeting” Scott.
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1943
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1946
1946
Dr. Joseph Stokes Jr. Awarded the Medal of Freedom
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President Harry S. Truman honored Dr. Stokes Jr. for his research on the value of gamma globulin (convalescent serum) for the treatment of hepatitis A and hepatitis B.
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1946
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1950s
1950s
Scientists Pioneered Use of Electron Microscopy
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Dr. Klaus Hummeler, shown here in 1954, was a pioneer in the use of electron microscopy.
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1954
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1956
1956
Spitz-Holter Valve Developed
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Drs. John Holter and Eugene Spitz developed the first working shunt valve to drain fluid for the treatment of hydrocephalus; the valve is now used throughout the world.
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1963
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1965
1965
Clinical Research Center Established
The Clinical Research Center was established for hard-to-diagnose pediatric diseases and the development of advanced treatments.
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1966
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1967
1967
Scientists Link Epstein-Barr Virus as Cause of Mononucleosis
Drs. Werner and Gertrude Henle, along with Dr. Klaus Hummeler, discover Epstein-Barr virus (EBV) causes infectious mononucleosis.
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1971
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1972
1972
Joseph Stokes Jr. Research Institute Created
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The Joseph Stokes Jr. Research Institute contained 70,000 square feet dedicated to research. Dr. Klaus Hummeler was its first director.
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1973
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1974
1974
Hospital Moves to West Philadelphia Location
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CHOP moved to its location at 3401 Civic Center Boulevard in West Philadelphia, and the first DNA Laboratory in Philadelphia was established.
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1983
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1988
1988
Scientists Show Value of Cryotherapy for Premature Infants
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Dr. Graham Quinn and colleagues proved the value of cryotherapy to destroy abnormal vessel growth to prevent blindness in infants born prematurely.
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1980s
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1992-1995
1992-1995
Scientists Revealed Mechanisms Underlying HIV Infection
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Dr. Terri Finkel and team showed that HIV primes uninfected T cells for suicide, reducing their ability to fight infection, and that HIV renders some of its cells death-resistant.
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1995
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1995
1995
Center for Fetal Diagnosis and Treatment Launched
The Center for Fetal Diagnosis and Treatment opened under the leadership of N. Scott Adzick, MD, MMM, a pioneer in the field of fetal medicine.
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1997
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1997-2006
1997-2006
First Centers of Emphasis Named
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1999
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2006
2006
FDA Approved Rotavirus Vaccine
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The U.S. Food and Drug Administration approved rotavirus vaccine, Rotateq®, and it was subsequently included in the CDC’s recommended vaccine schedule for children.
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2010
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2012
2012
CAR T-cell Therapy Administered to First Pediatric Patient
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Dr. Stephan Grupp administered CAR T-cell therapy to the first pediatric patient for relapsed acute lymphoblastic leukemia, Emily Whitehead, who remains in remission.
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2015
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2016
2016
Roberts Collaborative for Genetics and Individualized Medicine Created
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The initiative applies genetic testing technology to individualize diagnostics in pediatrics and then translate patients’ unique genetic blueprints to inform clinical management.
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2018
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2018
2018
First Gene Therapy for a Genetic Disease Approved
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Dr. Katherine High and University of Pennsylvania colleagues developed a safe gene therapy, Luxterna®, for Leber congenital amaurosis, a rare, inherited form of retinal blindness.
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2019
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2021
2021
FDA Approved Harmony™ Transcatheter Pulmonary Valve
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CHOP was a lead enrollment site in the clinical trial leading to approval of a device that allows for pulmonary valve replacement via a minimally invasive catheter-based procedure.
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2021
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2022
2022
FDA Approved
Beti-celThe FDA approved the first potentially curative therapy for patients who require regular red blood cell transfusions to treat beta thalassemia.
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2022
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