Paul
 
A.
 
Offit
Email: 
offit@email.chop.edu
Address: 
Division of Infectious Diseases Abramson Research Building, Room 1202D 3615 Civic Center Blvd.
(215) 590-2020
Affiliations
Expertise

Research Interests
rotavirus, rotavirus vaccine, intestinal immunity, vaccines, vaccine safety

Key words: rotavirus, rotavirus vaccine, intestinal immunity.

Description of Research
We studied the genetics of rotavirus virulence, rotavirus neutralization phenotype and protein-specificities of rotavirus-specific cytotoxic T lymphocytes as a prelude to making a bovine-human reassortant rotavirus vaccine. The vaccine, RotaTeq, was licensed by the Food and Drug Administration in February, 2006.

Rotation Projects for 2006-2007
None. The laboratory closed in December, 2005. My professional time is devoted to running the Vaccine Education Center at the Children?s Hospital of Philadelphia: an international center that creates educational materials for parents and healthcare professionals and runs on an endowment yielding about $500,000 per year.

Appointments
Clinical Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1984 – 1985)
Assistant Professor of Pediatrics at University of Pennsylvania School of Medicine (1987 – 1992)
Associate Professor of Pediatrics at University of Pennsylvania School of Medicine (1992 – 2001)
Professor of Pediatrics at University of Pennsylvania School of Medicine (2001– present)
Education
M.D., University of Maryland (1977)
B.S., Tufts University (1973)
Selected Publications
Offit, P.A. and Hackett, C.J.. Addressing parents? concerns: Do vaccines cause allergic or autoimmune diseases?. Pediatrics. Vol 111. 2003:653-659.
Chow, A.A., Moser C.A., Speaker, T.J., and Offit, P.A.. Determination of efficiency of attachment of biotinylated antibodies to avidin-linked, aqueous-based microcapsules by flow cytometry.. J. Immunol. Methods. Vol 277. 2003:135-139.
Offit, P.A., Jew, R.K.. Addressing parents? concerns: Do vaccines contain harmful preservatives, adjuvants, additives, or residuals?. Pediatrics [in press]. 2003.
Offit, P.A. and Coffin, S.E.. Communicating science to the public: MMR vaccine and autism.. Vaccine [in press]. 2003.
Offit, PA, HF Clark, and RL Ward.. Current state of development of human rotavirus vaccines.. Viral Gastroenteritis. Elsevier Science BV, Amsterdam, The Netherlands; 2003:345-356.
Ward RL, HF Clark, PA Offit, and RI Glass.. Live vaccine strategies to prevent rotavirus disease.. New Generation Vaccines. Marcel Dekker, Inc., New York, NY; 2003 in press.
Clark, H F., P.A. Offit, R.I. Glass, and RM Ward.. Rotavirus vaccines.. Vaccines, 4th Edition. W.B. Saunders; 2003 in press.
Offit P.A., and C.J. Hackett.. Do vaccines weaken, overwhelm, or alter the normal balance of the immune system.. Vaccines, 4th Edition. W.B. Saunders; 2003 in press.
Offit, PA.. Getting "fully informed" about vaccines.. Contemp. Pediatr.. 2003 in press.
Offit, P.A.. The power of 'box a'.. Expert Rev Vaccines. Vol 2. 2003:1-3.