Research at The Children’s Hospital of Philadelphia is enhanced by its state-of-the-art facilities. Laboratory research is conducted in the Leonard and Madlyn Abramson Pediatric Research Center, first opened in 1995, and in the Colket Translational Research Building, which was opened in 2009. In addition to 93 lab modules, the Abramson Pediatric Research Center also houses numerous core facilities, which provide state-of-the-art shared research resources to Hospital investigators. The Colket Translational Research building features office and research space, and is home to several core facilities as well as a number of administrative departments.

Most of the Hospital’s clinical research is housed in the North Campus of the Hospital. At 3535 Market St. more than 150,000 square feet are dedicated to research. Clinical research space, research support services and Centers of Emphasis, such as the Center for Biomedical Informatics are located at 3535 Market St. This facility, along with the Behavioral Health Center at 3440 Market St., and the outpatient Clinical and Translational Research Center at 3550 Market St., are an important hub for clinical research outside the main Hospital buildings.

Much clinical research also takes place in the Hospital’s clinical facilities — the Main Hospital, the Wood Ambulatory Center and the Children’s Seashore House. The Clinical Trials Office and the Clinical and Translational Research Center are located on the main campus.

The continued expansion of Children’s Hospital’s enterprise — by adding as much as 1.5 million square feet on land immediately adjacent to its main campus in a new Ambulatory Care Center— is currently underway. This expansion will bring clinical and laboratory researchers into closer proximity with ambulatory patient care, consistent with the idea that every patient may potentially become involved in a research project.

It is also anticipated that the locus for clinical research will expand beyond the main campus to increasingly utilize the Hospital’s ambulatory network. Additionally, the Hospital’s facility development plans include new space for clinical cores, support mechanisms and research program staff on the Hospital's main campus.